ISSN 1671-5411 CN 11-5329/R

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Volume 17 Issue 11
Dec.  2020
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Article Contents
Myunhee Lee, Dae-Won Kim, Mahn-Won Park, Kyusup Lee, Kiyuk Chang, Wook Sung Chung, Tae Hoon Ahn, Myung Ho Jeong, Seung-Woon Rha, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyung Kuk Hwang, Shung Chull Chae, Kwon-Bae Kim, Young Jo Kim, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae, Ji-Hoon Jung, on behalf of KAMIR-NIH registry investigators. Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry. J Geriatr Cardiol 2020; 17(11): 680-693. doi: 10.11909/j.issn.1671-5411.2020.11.006
Citation: Myunhee Lee, Dae-Won Kim, Mahn-Won Park, Kyusup Lee, Kiyuk Chang, Wook Sung Chung, Tae Hoon Ahn, Myung Ho Jeong, Seung-Woon Rha, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyung Kuk Hwang, Shung Chull Chae, Kwon-Bae Kim, Young Jo Kim, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae, Ji-Hoon Jung, on behalf of KAMIR-NIH registry investigators. Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry. J Geriatr Cardiol 2020; 17(11): 680-693. doi: 10.11909/j.issn.1671-5411.2020.11.006

Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

doi: 10.11909/j.issn.1671-5411.2020.11.006
More Information
  • Corresponding author:

    Dae-Won Kim, E-mail: mirinesilver@catholic.ac.kr

  • Received Date: 2020-08-25
  • Accepted Date: 2020-11-27
  • Rev Recd Date: 2020-11-08
  • Available Online: 2020-11-28
  • Publish Date: 2020-11-28
  •  Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention (PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction (AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13, 104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH) between November 2011 and December 2015 were classified into male (n = 8021, 75.9%) and female (n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events (MACCE) in women with those in men after AMI by using propensity score (PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction (NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population (30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585; 1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328; TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P= 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.
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