Effects of the total physical activity and its changes on incidence, progression, and remission of hypertension

Can CAI; Fang-Chao LIU; Jian-Xin LI; Ke-Yong HUANG; Xue-Li YANG; Ji-Chun CHEN; Xiao-Qing LIU; Jie CAO; Shu-Feng CHEN; Chong SHEN; Ling YU; Fang-Hong LU; Xian-Ping WU; Lian-Cheng ZHAO; Ying LI; Dong-Sheng HU; Jian-Feng HUANG; Xiao-Yang ZHOU; Xiang-Feng LU; Dong-Feng GU

doi:10.11909/j.issn.1671-5411.2021.03.002

Volume 18 Issue 3

Mar. 2021

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Article Navigation > Journal of Geriatric Cardiology > 2021 > 18(3): 175-184

Please cite this article as: CAI C, LIU FC, LI JX, HUANG KY, YANG XL, CHEN JC, LIU XQ, CAO J, CHEN SF, SHEN C, YU L, LU FH, WU XP, ZHAO LC, LI Y, HU DS, HUANG JF, ZHOU XY, LU XF, GU DF. Effects of the total physical activity and its changes on incidence, progression, and remission of hypertension. J Geriatr Cardiol 2021; 18(3): 175−184. DOI: 10.11909/j.issn.1671-5411.2021.03.002

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Please cite this article as: CAI C, LIU FC, LI JX, HUANG KY, YANG XL, CHEN JC, LIU XQ, CAO J, CHEN SF, SHEN C, YU L, LU FH, WU XP, ZHAO LC, LI Y, HU DS, HUANG JF, ZHOU XY, LU XF, GU DF. Effects of the total physical activity and its changes on incidence, progression, and remission of hypertension. J Geriatr Cardiol 2021; 18(3): 175−184. DOI: 10.11909/j.issn.1671-5411.2021.03.002

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Effects of the total physical activity and its changes on incidence, progression, and remission of hypertension

doi: 10.11909/j.issn.1671-5411.2021.03.002

1.
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
2.
Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
3.
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, China
4.
Division of Epidemiology, Guangdong Provincial People’s Hospital and Cardiovascular Institute, Guangzhou 510080, China
5.
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
6.
Department of Cardiology, Fujian Provincial Hospital, Fuzhou 350014, China
7.
Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China
8.
Sichuan Center for Disease Control and Prevention, Chengdu 610041, China
9.
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen 518060, China

Funds: This study was supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2019-I2M-2-003 and 2017-I2M-1-004), National Key Research & Development Program of China (2018YFE0115300 and 2017YFC0211700, and 2017YFC0908401), and the National Natural Science Foundation of China (91643208). The sources of funding had no role in study design, data collection, analyses, interpretation, and decision to submit the article for publication

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Corresponding author: xiaoyangzh@whu.edu.cn; luxf@pumc.edu.cn
Available Online: 2021-04-07
Publish Date: 2021-03-31

Abstract

Abstract

OBJECTIVES Moderate to vigorous physical activity is recommended to prevent hypertension according to the current guidelines. However, the degree to which the total physical activity (TPA) and its changes benefit normotensives and hypertensives is uncertain. We aimed to examine the effects of TPA and its changes on the incidence, progression, and remission of hypertension in the large-scale prospective cohorts. METHODS A total of 73,077 participants (55,101 normotensives and 17,976 hypertensives) were eligible for TPA analyses. During a mean follow-up of 7.16 years (394,038 person-years), 12,211 hypertension cases were identified. TPA was estimated as metabolic equivalents and categorized into quartiles. Cox proportional hazards regression and multivariable logistic regression were used to estimate associations of TPA and changes in TPA with incident hypertension and progression/remission of hypertension. RESULTS Compared with the lowest quartile of TPA, normotensives at the third and the highest quartile had a decreased risk of incident hypertension, with hazard ratios (HRs) of 0.86 [95% confidence interval (CI): 0.81−0.91] and 0.81 (95% CI: 0.77−0.86), respectively. Hypertensives at the highest quartile of TPA demonstrated a decreased risk of progression of hypertension [odds ratio (OR) = 0.87, 95% CI: 0.79−0.95], and an increased probability of hypertension remission (OR = 1.17, 95% CI: 1.05−1.29). Moreover, getting active from a sedentary lifestyle during the follow-up period could reduce 25% (HR = 0.75, 95% CI: 0.58−0.96) risk of incident hypertension, whereas those becoming sedentary did not achieve benefit from initially being active. CONCLUSIONS Our findings indicated that increasing and maintaining TPA levels could benefit normotensives, whereas higher TPA levels were needed to effectively control progression and improve remission of hypertension. Physical activity played undoubtedly an essential role in both primary and secondary prevention of hypertension.
- physical activity,
- incident hypertension,
- progression of hypertension,
- remission of hypertension,
- metabolic equivalent

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References(31)

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