Associations between low-density lipoprotein cholesterol and haemorrhagic stroke

Yun-Yan XIE; Shi-Meng LIU; Qian ZHANG; Yu JIA; Jian-Ping DING

doi:10.11909/j.issn.1671-5411.2021.03.011

Volume 18 Issue 3

Mar. 2021

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Article Navigation > Journal of Geriatric Cardiology > 2021 > 18(3): 204-209

Please cite this article as: XIE YY, LIU SM, ZHANG Q, JIA Y, DING JP. Associations between low-density lipoprotein cholesterol and haemorrhagic stroke. J Geriatr Cardiol 2021; 18(3): 204−209. DOI: 10.11909/j.issn.1671-5411.2021.03.011

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Please cite this article as: XIE YY, LIU SM, ZHANG Q, JIA Y, DING JP. Associations between low-density lipoprotein cholesterol and haemorrhagic stroke. J Geriatr Cardiol 2021; 18(3): 204−209. DOI: 10.11909/j.issn.1671-5411.2021.03.011

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Associations between low-density lipoprotein cholesterol and haemorrhagic stroke

doi: 10.11909/j.issn.1671-5411.2021.03.011

Yun-Yan XIE^{1, *},
Shi-Meng LIU^{2, 3, *},
Qian ZHANG¹,
Yu JIA¹,
Jian-Ping DING^{1
,
,}

1.
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
2.
Department of Neurology, University of California, Irvine, Irvine, California, USA
3.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Corresponding author: djp192001@aliyun.com
Available Online: 2021-01-28
Publish Date: 2021-03-31

Abstract

Abstract

OBJECTIVE To investigate the associations between the blood concentrations of low-density lipoprotein cholesterol (LDL-C) and the clinical features of haemorrhagic stroke. METHODS This study analysed the data from patients with acute haemorrhagic stroke at a comprehensive stroke centre from 2013 to 2018. Patients were stratified into three groups according to their baseline LDL-C levels: < 70, 70 to < 100 and ≥ 100 mg/dL. We used multivariate logistic regression models to analyse the associations between LDL-C and the risks of having severe neurological deficits (National Institute Health Stroke Scale [NIHSS] scores ≥ 15) and unfavourable outcomes (modified Rankin Scale [mRS] scores>2) at discharge. RESULTS Six-hundred and six patients were analysed. Their median age was 58 years. Among the patients, 75 (12%) patients had LDL-C levels < 70 mg/dL, 194 (32%) patients had LDL-C levels between 70 to < 100 mg/dL and the other 337 (56%) patients had LDL-C levels ≥ 100 mg/dL. Patients with higher LDL-C levels were less likely to suffer severe neurological deficits (LDL-C: 70 to < 100 vs. < 70 mg/dL, adjusted odds ratio [OR]: 0.29, 95% CI: 0.15–0.57; LDL-C: ≥ 100 vs. < 70 mg/dL, adjusted OR = 0.27, 95% CI: 0.15–0.51) and to have unfavourable outcomes at discharge (LDL-C: 70 to < 100 vs. < 70 mg/dL, adjusted OR = 0.50, 95% CI: 0.29–0.87 and LDL-C: ≥ 100 vs. < 70 mg/dL, adjusted OR = 0.46, 95% CI: 0.28–0.78). CONCLUSIONS An LDL-C level < 70 mg/dL was independently associated with severe neurological deficits of haemorrhagic stroke and may increase the risks of unfavourable outcomes at discharge.

^*The authors contributed equally to this manuscript

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References(17)

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