ISSN 1671-5411 CN 11-5329/R
Volume 18 Issue 8
Aug.  2021
Turn off MathJax
Article Contents
Please cite this article as: LU MM, PENG P, Hatsukami TS, YUAN F, CUI YY, ZHANG LC, QIAO HY, YUAN C, CAI JM, ZHAO XH. A comparison of carotid atherosclerosis in symptomatic patients between 2002–2005 and 2012–2015 cohorts using multi-contrast magnetic resonance vessel wall imaging. J Geriatr Cardiol 2021; 18(8): 623−630. DOI: 10.11909/j.issn.1671-5411.2021.08.006
Citation: Please cite this article as: LU MM, PENG P, Hatsukami TS, YUAN F, CUI YY, ZHANG LC, QIAO HY, YUAN C, CAI JM, ZHAO XH. A comparison of carotid atherosclerosis in symptomatic patients between 2002–2005 and 2012–2015 cohorts using multi-contrast magnetic resonance vessel wall imaging. J Geriatr Cardiol 2021; 18(8): 623−630. DOI: 10.11909/j.issn.1671-5411.2021.08.006

A comparison of carotid atherosclerosis in symptomatic patients between 2002–2005 and 2012–2015 cohorts using multi-contrast magnetic resonance vessel wall imaging

doi: 10.11909/j.issn.1671-5411.2021.08.006
*The authors contributed equally to this manuscript
More Information
  •  OBJECTIVE To compare the morphological and compositional characteristics of carotid plaques in two cohorts (2002−2005 and 2012−2015) of Chinese patients using magnetic resonance vessel wall imaging. METHODS Symptomatic patients with carotid atherosclerotic plaques who underwent carotid vessel wall magnetic resonance imaging between 2002−2005 and 2012−2015 were retrospectively recruited. Plaque morphology [including mean wall area, wall thickness, and maximum normalized wall index (NWI)] and composition [including calcification, intraplaque hemorrhage, and lipid-rich necrotic core (LRNC)] in symptomatic carotid arteries were evaluated and compared between patients in these two time periods. RESULTS A total of 258 patients, including 129 patients in the 2002−2005 cohort and 129 patients in the 2012−2015 cohort, were recruited. Statin use (49.6% vs. 32.6%, P = 0.004) and hypertension (76.0% vs. 62.8%, P = 0.015) were significantly more common in the 2012–2015 cohort than in the 2002−2005 cohort. Patients in the 2012−2015 cohort also exhibited significantly low plaque burden parameters (all P < 0.05), as well as a lower prevalence (68.2% vs. 89.9%, P < 0.001) and volume percentages of LRNC (11.2% ± 14.2% vs. 25.7% ± 17.7%, P < 0.001). These differences remained significant after adjustment for clinical factors. The differences in the volume percentages of LRNC also remained significant after an additional adjustment for maximum NWI (P < 0.001). CONCLUSIONS Patients in the 2012−2015 cohort had a lower plaque burden and volume percentages of LRNC in symptomatic carotid arteries than those in the 2002−2005 cohort. These findings indicate that carotid plaques in the recent cohort had a lower severity and vulnerability.
  • loading
  • [1]
    van den Bouwhuijsen QJ, Vernooij MW, Hofman A, et al. Determinants of magnetic resonance imaging detected carotid plaque components: the Rotterdam Study. Eur Heart J 2012; 33: 221−229. doi: 10.1093/eurheartj/ehr227
    Wasserman BA, Sharrett AR, Lai S, et al. Risk factor associations with the presence of a lipid core in carotid plaque of asymptomatic individuals using high-resolution MRI: the multi-ethnic study of atherosclerosis (MESA). Stroke 2008; 39: 329−335. doi: 10.1161/STROKEAHA.107.498634
    Tattersall MC, Gassett A, Korcarz CE, et al. Predictors of carotid thickness and plaque progression during a decade: the Multi-Ethnic Study of Atherosclerosis. Stroke 2014; 45: 3257−3262. doi: 10.1161/STROKEAHA.114.005669
    Brinjikji W, Lehman VT, Kallmes DF, et al. The effects of statin therapy on carotid plaque composition and volume: a systematic review and meta-analysis. J Neuroradiol 2017; 44: 234−240. doi: 10.1016/j.neurad.2016.12.004
    Li Y, Huang Z, Jin C, et al. Longitudinal change of perceived salt intake and stroke risk in a Chinese population. Stroke 2018; 49: 1332−1339. doi: 10.1161/STROKEAHA.117.020277
    Yang L, Shao J, Bian Y, et al. Prevalence of type 2 diabetes mellitus among inland residents in China (2000–2014): a meta-analysis. J Diabetes Investig 2016; 7: 845−852. doi: 10.1111/jdi.12514
    Li Y, Yang L, Wang L, et al. Burden of hypertension in China: a nationally representative survey of 174, 621 adults. Int J Cardiol 2017; 227: 516−523. doi: 10.1016/j.ijcard.2016.10.110
    Huang BT, Peng Y, Huang FY, et al. Trends in prescribing rate of statins at discharge and modifiable factors in patients with atherosclerotic cardiovascular disease. Intern Emerg Med 2017; 12: 1121−1129. doi: 10.1007/s11739-017-1694-9
    Hackam DG, Spence JD. Decline in the severity of carotid atherosclerosis and associated risk factors from 2002 to 2014. Stroke 2018; 49: 2786−2788. doi: 10.1161/STROKEAHA.118.021445
    Liu Y, Wang M, Zhang B, et al. Size of carotid artery intraplaque hemorrhage and acute ischemic stroke: a cardiovascular magnetic resonance Chinese atherosclerosis risk evaluation study. J Cardiovasc Magn Reson 2019; 21: 36. doi: 10.1186/s12968-019-0548-1
    Lu M, Peng P, Cui Y, et al. Association of progression of carotid artery wall volume and recurrent transient ischemic attack or stroke: a magnetic resonance imaging study. Stroke 2018; 49: 614−620. doi: 10.1161/STROKEAHA.117.019422
    Takaya N, Yuan C, Chu B, et al. Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation 2005; 111: 2768−2775. doi: 10.1161/CIRCULATIONAHA.104.504167
    Gao S, van’t Klooster R, van Wijk DF, et al. Repeatability of in vivo quantification of atherosclerotic carotid artery plaque components by supervised multispectral classification. MAGMA 2015; 28: 535−545. doi: 10.1007/s10334-015-0495-2
    Chu B, Kampschulte A, Ferguson MS, et al. Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study. Stroke 2004; 35: 1079−1084. doi: 10.1161/01.STR.0000125856.25309.86
    Cai JM, Hatsukami TS, Ferguson MS, et al. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 2002; 106: 1368−1373. doi: 10.1161/01.CIR.0000028591.44554.F9
    Kerwin W, Xu D, Liu F, et al. Magnetic resonance imaging of carotid atherosclerosis: plaque analysis. Top Magn Reson Imaging 2007; 18: 371−378. doi: 10.1097/rmr.0b013e3181598d9d
    Yuan C, Mitsumori LM, Ferguson MS, et al. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation 2001; 104: 2051−2056. doi: 10.1161/hc4201.097839
    Hatsukami TS, Ross R, Polissar NL, et al. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 2000; 102: 959−964. doi: 10.1161/01.CIR.102.9.959
    Vancheri F, Backlund L, Strender LE, et al. Time trends in statin utilisation and coronary mortality in Western European countries. BMJ Open 2016; 6: e010500. doi: 10.1136/bmjopen-2015-010500
    Choudhry NK, Dugani S, Shrank WH, et al. Despite increased use and sales of statins in India, per capita prescription rates remain far below high-income countries. Health Aff (Millwood) 2014; 33: 273−282. doi: 10.1377/hlthaff.2013.0388
    Wu Y, Huxley R, Li L, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from the China National Nutrition and Health Survey 2002. Circulation 2008; 118: 2679−2686. doi: 10.1161/CIRCULATIONAHA.108.788166
    Campbell NRC, Zhang XH. Hypertension in China: time to transition from knowing the problem to implementing the solution. Circulation 2018; 137: 2357−2359. doi: 10.1161/CIRCULATIONAHA.118.034028
    Sun B, Li X, Liu X, et al. Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2017; 16: 111. doi: 10.1186/s12933-017-0592-9
    Kwee RM, van Oostenbrugge RJ, Mess WH, et al. MRI of carotid atherosclerosis to identify TIA and stroke patients who are at risk of a recurrence. J Magn Reson Imaging 2013; 37: 1189−1194. doi: 10.1002/jmri.23918
    Boussel L, Arora S, Rapp J, et al. Atherosclerotic plaque progression in carotid arteries: monitoring with high-spatial-resolution MR imaging-multicenter trial. Radiology 2009; 252: 789−796. doi: 10.1148/radiol.2523081798
    Herder M, Arntzen KA, Johnsen SH, et al. Long-term use of lipid-lowering drugs slows progression of carotid atherosclerosis: the Tromso study 1994 to 2008. Arterioscler Thromb Vasc Biol 2013; 33: 858−862. doi: 10.1161/ATVBAHA.112.300767
    Faeh D, Gutzwiller F, Bopp M. Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland. Circulation 2009; 120: 495−501. doi: 10.1161/CIRCULATIONAHA.108.819250
    Kaufman JD, Adar SD, Barr RG, et al. Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study. Lancet 2016; 388: 696−704. doi: 10.1016/S0140-6736(16)00378-0
    Narumi S, Sasaki M, Natori T, et al. Carotid plaque characterization using 3D T1-weighted MR imaging with histopathologic validation: a comparison with 2D technique. AJNR Am J Neuroradiol 2015; 36: 751−756. doi: 10.3174/ajnr.A4197
    Sun J, Zhao XQ, Balu N, et al. Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study. Int J Cardiovasc Imaging 2015; 31: 95−103. doi: 10.1007/s10554-014-0532-7
  • 加载中


    通讯作者: 陈斌,
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(4)

    Article Metrics

    Article views (120) PDF downloads(15) Cited by()
    Proportional views


    DownLoad:  Full-Size Img  PowerPoint