ISSN 1671-5411 CN 11-5329/R
Volume 18 Issue 11
Nov.  2021
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Please cite this article as: Mohrez Y, Gloekler S, Schnupp S, Allakkis W, Liu XX, Fuerholz M, Brachmann J, Windecker S, Achenbach S, Meier B, Kleinecke C. Clinical benefit of left atrial appendage closure in octogenarians. J Geriatr Cardiol 2021; 18(11): 886−896. DOI: 10.11909/j.issn.1671-5411.2021.11.003
Citation: Please cite this article as: Mohrez Y, Gloekler S, Schnupp S, Allakkis W, Liu XX, Fuerholz M, Brachmann J, Windecker S, Achenbach S, Meier B, Kleinecke C. Clinical benefit of left atrial appendage closure in octogenarians. J Geriatr Cardiol 2021; 18(11): 886−896. DOI: 10.11909/j.issn.1671-5411.2021.11.003

Clinical benefit of left atrial appendage closure in octogenarians

doi: 10.11909/j.issn.1671-5411.2021.11.003
*The authors contributed equally to this manuscript
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  •  OBJECTIVES  Whether left atrial appendage closure (LAAC) in octogenarians yield similar net clinical benefit compared to younger patients, was the purpose of the present study.  METHODS Two real-world LAAC registries, enrolling 744 consecutive Amplatzer and Watchman patients from 2009 to 2018, were retrospectively analyzed.  RESULTS  All events are reported per 100 patient-years. Two hundred and sixty one octogenarians and 483 non-octogenarians with a mean follow-up of 1.7 ± 1.3 and 2.3 ± 1.6 years, and a total of 1,502 patient-years were included. Octogenarians had a higher risk for stroke (CHA2DS2-VASc score: 5.2 ± 1.2 vs. 4.3 ± 1.7, P < 0.0001) and bleeding (HAS-BLED score: 3.3 ± 0.8 vs. 3.1 ± 1.1, P = 0.001). The combined safety endpoint of major periprocedural complications and major bleeding events at follow-up was comparable (30/446, 6.7% vs. 47/1056, 4.4%; hazard ratio [HR] = 1.2; 95% confidence interval [CI]: 0.73−1.98; P = 0.48) between the groups. The efficacy endpoint of all-cause stroke, systemic embolism, and cardiovascular/unexplained death occurred more often in octogenarians (61/446, 13.7% vs. 80/1056, 7.6%; HR = 7.0; 95% CI: 4.53−10.93; P < 0.0001). Overall, octogenarians had a lower net clinical benefit, i.e., the composite of all above mentioned hazards, from LAAC compared to younger patients (82/446, 18.4% vs. 116/1056, 11.0%; HR = 4.6; 95% CI: 3.11−7.0; P < 0.0001). Compared to the anticipated stroke rate, the observed rate decreased by 41% in octogenarians and 53% in non-octogenarians. The observed bleeding rate was reduced by 10% octogenarians and 41% non-octogenarians.  CONCLUSIONS LAAC can be performed with similar safety in octogenarians as compared to younger patients. On the long-term, it both reduces stroke and bleeding events, although to a lesser extent than in non-octogenarians.
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