ISSN 1671-5411 CN 11-5329/R
Yong-Fu Xiao. Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage. J Geriatr Cardiol 2011; 8(3): 147-158. doi: 10.3724/SP.J.1263.2011.00147
Citation: Yong-Fu Xiao. Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage. J Geriatr Cardiol 2011; 8(3): 147-158. doi: 10.3724/SP.J.1263.2011.00147

Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage

doi: 10.3724/SP.J.1263.2011.00147
  • Received Date: 2011-06-29
  • Action potentials generated in the sinoatrial node (SAN) dominate the rhythm and rate of a healthy human heart. Subsequently, these action potentials propagate to the whole heart via its conduction system. Abnormalities of impulse generation and/or propagation in a heart can cause arrhythmias. For example, SAN dysfunction or conduction block of the atrioventricular node can lead to serious bradycardia which is currently treated with an implanted electronic pacemaker. On the other hand, conduction damage may cause reentrant tachyarrhythmias which are primarily treated pharmacologically or by medical device-based therapies, including defibrillation and tissue ablation. However, drug therapies sometimes may not be effective or are associated with serious side effects. Device-based therapies for cardiac arrhythmias, even with well developed technology, still face inadequacies, limitations, hardware complications, and other challenges. Therefore, scientists are actively seeking other alternatives for antiarrhythmic therapy. In particular, cells and genes used for repairing cardiac conduction damage/defect have been investigated in various studies both in vitro and in vivo. Despite the complexities of the excitation and conduction systems of the heart, cell and gene-based strategies provide novel alternatives for treatment or cure of cardiac arrhythmias. This review summarizes some highlights of recent research progress in this field.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1741) PDF downloads(4423) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return