ISSN 1671-5411 CN 11-5329/R
Gang Huang, Hua Zhong, He-Man Re, Hong-Wei Mao, Qiang Niu, Ye-Hong Chi. Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks. J Geriatr Cardiol 2012; 9(1): 33-37. doi: 10.3724/SP.J.1263.2012.00033
Citation: Gang Huang, Hua Zhong, He-Man Re, Hong-Wei Mao, Qiang Niu, Ye-Hong Chi. Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks. J Geriatr Cardiol 2012; 9(1): 33-37. doi: 10.3724/SP.J.1263.2012.00033

Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks

doi: 10.3724/SP.J.1263.2012.00033
Funds:

This work was supported by the basal and clinical studies funds of Shihezi University Medical College and its first affiliated hospital (LHJJ2010B06).

  • Received Date: 2011-10-17
  • Objective To explore the relationship between polymorphisms of XbaI and MspI loci of apolipoprotein B (ApoB) gene and -75 bp, +83 bp loci of apolipoprotein AI (ApoAI) gene and coronary heart disease (CHD) in Kazaks of Xinjiang Uyghur Autonomous Region, China. Methods These loci were analyzed by PCR-restriction fragment length polymorphism (PCR-PFLP). Two hundred and five patients with CHD and two hundred and thirty six controls were involved. Results There were significant distinctions among low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and the ApoAI/ApoB ratio between the two groups, but no significant distinction among the polymorphism frequencies of the four sites between the two groups. The polymorphism coalition frequency of X--/Ms++/M1+-/M2++ (named Coalition 11) was significantly higher in CHD compared to the control group (14.6% vs. 7.2%, P Conclusion Coalition 11 of the 4 loci polymorphisms of the ApoB and ApoAI genes was correlated with CHD in Kazaks, and perhaps the ratio of ApoAI/ApoB was the most diagnostic parameter related with CHD among all lipid parameters. CHD may also be associated with Coalition 5, and, perhaps, Coalition 3 may have been confirmed as a protection factor against CHD, if more samples were enrolled.
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