ISSN 1671-5411 CN 11-5329/R
Su-Yan Bian, Hong-Yang Guo, Ping Ye, Lei-Ming Luo, Hong-Mei Wu, Wen-Kai Xiao, Li-Ping Qi, He-Peng Yu, Liu-Fa Duan. Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function. J Geriatr Cardiol 2012; 9(2): 158-165. doi: 10.3724/SP.J.1263.2012.03051
Citation: Su-Yan Bian, Hong-Yang Guo, Ping Ye, Lei-Ming Luo, Hong-Mei Wu, Wen-Kai Xiao, Li-Ping Qi, He-Peng Yu, Liu-Fa Duan. Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function. J Geriatr Cardiol 2012; 9(2): 158-165. doi: 10.3724/SP.J.1263.2012.03051

Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function

doi: 10.3724/SP.J.1263.2012.03051
Funds:

Capital Medical Development Fund (2009-2038) of Beijing

  • Received Date: 2012-03-05
  • Objective Both decreased glomerular filtration rate (GFR) and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. Methods In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR ≥ 60 mL/minutes per 1.73 m2 estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness were estimated simultaneously by measuring carotid-femoral pulse wave velocity (PWVcf) and carotid-radial PWV (PWVcr) using a validated automatic device. Augmentation Index at heart rate 75 beats/min (AIx-75) was measured by pulse wave analysis as a composite parameter reflecting both large and distal arterial properties. Results The mean estimated GFR (eGFR) of the study group was 100.05 ± 23.26 mL/minute per 1.73 m2. Subjects were grouped by tertiles of eGFR level. PWVcf and AIx-75 increased ongoing from the top to the bottom eGFR tertile, while the values of PWVcr were comparable. Both univariate Pearson correlations and multiple stepwise regression analyses showed that eGFR significantly correlated to PWVcf, but not to PWVcr and AIx-75. Conclusions In Chinese women with normal to mildly impaired renal function, decreased eGFR affected carotid-to-femoral rather than carotid-to-radial stiffening. This provides rational to conduct future prospective studies to investigate predictors of atherosclerosis in this population.
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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