Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae，Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Tianjin, China;Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
This work was supported by the National Natural Sci-ence Foundation of China (81173592, 81125024), Tianjin Applied Basic Research and Frontier Technological Pro?gram (11JCZDJC21100), Program for New Century Ex?cellent Talents in University of Ministry of Education of China (NCET-13-0935, "Major drug discovery"). National Science and Technology Major Project of the Ministry of Science and Technology of China (2012ZX09101212) and the Program for Changjiang Scholars and Innovative Re?search Team in University, PCSIRT (IRT0973IRT1276).
The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems. The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fi-broblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth. These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis. Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth. Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors. In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth. And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases.