ISSN 1671-5411 CN 11-5329/R
Song ZHANG, Yong-Yi BAI, Lei-Ming LUO, Wen-Kai XIAO, Hong-Mei WU, Ping YE. Association between serum homocysteine and arterial stiffness in elderly: a community-based study. J Geriatr Cardiol 2014; 11(1): 32-38. doi: 10.3969/j.issn.1671-5411.2014.01.007
Citation: Song ZHANG, Yong-Yi BAI, Lei-Ming LUO, Wen-Kai XIAO, Hong-Mei WU, Ping YE. Association between serum homocysteine and arterial stiffness in elderly: a community-based study. J Geriatr Cardiol 2014; 11(1): 32-38. doi: 10.3969/j.issn.1671-5411.2014.01.007

Association between serum homocysteine and arterial stiffness in elderly: a community-based study

doi: 10.3969/j.issn.1671-5411.2014.01.007
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This work was supported by grants from the Key National Basic Research Program of China (2013CB530804) and Nature Science Foundation of China (81270941) to Ye P, and the Nature Science Foundation of China (81100878) and the Beijing Nova Program (Z121107002513124) to Bai Y.

  • Received Date: 2013-11-07
  • Rev Recd Date: 2013-11-07
  • Publish Date: 2014-03-20
  • Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older populations. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arterial stiffness (carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV) in 780 participants (46.3% men, mean age 71.9 years (ranging 65–96 years old)) from two communities of Beijing, China. Arterial stiffness was measured within two days of the time of biomarker measurement. Results In multiple-adjusted models, homocysteine levels was strongly associated with the carotid-femoral PWV (standardized β = 0.13, P Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.
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