ISSN 1671-5411 CN 11-5329/R
Tao LIN, Xing DU, Rong BAI, Ying-Wei CHEN, Rong-Hui YU, De-Yong LONG, Ri-Bo TANG, Cai-Hua SANG, Song-Nan LI, Chang-Sheng MA, Jian-Zeng DONG. Long-term results of single-procedure catheter ablation for atrial fibrillationin pre- and post-menopausal women. J Geriatr Cardiol 2014; 11(2): 120-125. doi: 10.3969/j.issn.1671-5411.2014.02.005
Citation: Tao LIN, Xing DU, Rong BAI, Ying-Wei CHEN, Rong-Hui YU, De-Yong LONG, Ri-Bo TANG, Cai-Hua SANG, Song-Nan LI, Chang-Sheng MA, Jian-Zeng DONG. Long-term results of single-procedure catheter ablation for atrial fibrillationin pre- and post-menopausal women. J Geriatr Cardiol 2014; 11(2): 120-125. doi: 10.3969/j.issn.1671-5411.2014.02.005

Long-term results of single-procedure catheter ablation for atrial fibrillationin pre- and post-menopausal women

doi: 10.3969/j.issn.1671-5411.2014.02.005
Funds:

This study was supported by grants from the “Twelfth Five Year” National Science and Technology support program of China (No. 2012BAI14B0) and Beijing City Board of Education technology development project (No. KZ201210025030).

  • Received Date: 2014-02-11
  • Rev Recd Date: 2014-03-28
  • Publish Date: 2014-06-10
  • Objectives To address whether menopause affects outcome of catheter ablation (CA) for atrial fibrillation (AF) by comparing the safety and long-term outcome of a single-procedure in pre- and post-menopausal women. Methods A total of 743 female patients who underwent a single CA procedure of drug-refractory AF were retrospectively analyzed. The differences in clinical presentation and outcomes of CA for AF between the pre-menopausal women (PreM group, 94 patients, 12.7%) and the post-menopausal women (PostM group, 649 patients, 87.3%) were assessed. Results The patients in the PreM group were younger (P P P = 0.005) than those in the PostM group. The two groups were similar with regards to the proportion of concomitant mitral valve regurgitation coronary artery disease, left atrium dimensions, and left ventricular ejection fraction. The overall rate of complications related to AF ablation was similar in both groups (P = 0.385). After 43 (16–108) months of follow-up, the success rate of ablation was 54.3% in the PreM group and 54.2% in the PostM group (P = 0.842). The overall freedom from atrial tachyarrhythmia recurrence was similar in both groups. Menopause was not found to be an independent predictive factor of the recurrence of atrial tachyarrhythmia. Conclusions The long-term outcomes of single-procedure CA for AF are similar in pre- and post-menopausal women. Results indicated that CA of AF appears to be as safe and effective in pre-menopausal women as in post-menopausal women.
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