ISSN 1671-5411 CN 11-5329/R
Rui Wang, Jiyuan Lu, Yongping Jia, Yuping Gao, Chunyu Fan, Fang Li. Relationship between platelet P-selectin and severity of acute coronary syndromes. J Geriatr Cardiol 2008; 5(3): 146-149.
Citation: Rui Wang, Jiyuan Lu, Yongping Jia, Yuping Gao, Chunyu Fan, Fang Li. Relationship between platelet P-selectin and severity of acute coronary syndromes. J Geriatr Cardiol 2008; 5(3): 146-149.

Relationship between platelet P-selectin and severity of acute coronary syndromes

  • Publish Date: 2008-09-28
  • Objective Recent studies reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and severity of acute coronary syndromes. Methods One hundred and eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes (ACS) were enrolled in the study. Level of P-selectin expression was determined by flow cytometry. Platelet P-selectin level was expressed as the percentage of Pselectin positive platelet. Results The level of P-selectin was higher in patients with a single diseased coronary artery or multiple diseased arteries compared to those with normal coronary arteries. P-selectin expression was significantly and positively correlated with angiographic Gensini score (r=0.323, P=0.029). Multiple regression analyses showed that the association of the percentage of Pselectin–positive platelets with ACS was independent of other clinical factors. Conclusions Platelet P-selectin is associated with severity of acute coronary syndromes in patients with acute coronary syndromes.
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