ISSN 1671-5411 CN 11-5329/R
Xiaohui Duan, Yongfen Qi, Chaoshu Tang. Endoplasmic reticulum stress and cardiovascular diseases. J Geriatr Cardiol 2009; 6(1): 49-55.
Citation: Xiaohui Duan, Yongfen Qi, Chaoshu Tang. Endoplasmic reticulum stress and cardiovascular diseases. J Geriatr Cardiol 2009; 6(1): 49-55.

Endoplasmic reticulum stress and cardiovascular diseases

  • Publish Date: 2009-03-28
  • The endoplasmic reticulum (ER) serves several important functions, mainly post-translational modification, folding and assembly of newly synthesized secretary proteins, synthesizing lipids and cellular calcium storage. Various factors can disrupt ER homeostasis and disturb its functions, which leads to the accumulation of unfolded and misfolded proteins and to potential cellular dysfunction and pathological consequences, collectively termed ER stress. Recent progress suggests that ER stress plays a key role in the immune response, diabetes, tumor growth, and some neurodegenerative diseases. In particular, ER stress is involved in several processes of cardiovascular diseases, such as ischemia/reperfusion injury, cardiomyopathy, cardiac hypertrophy, heart failure, and atherosclerosis. Further research on the relation of ER stress to cardiovascular diseases will greatly enhance the understanding of these pathological processes and provide novel avenues to potential therapies.
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