ISSN 1671-5411 CN 11-5329/R
Jian-Chun Wang, Yong Zhao, Jian-Hua Shao. Calcineurin signalling mechanisms in myocardial hypertrophy. J Geriatr Cardiol 2010; 7(4): 189-192.
Citation: Jian-Chun Wang, Yong Zhao, Jian-Hua Shao. Calcineurin signalling mechanisms in myocardial hypertrophy. J Geriatr Cardiol 2010; 7(4): 189-192.

Calcineurin signalling mechanisms in myocardial hypertrophy

  • Publish Date: 2010-12-28
  • Calcineurin dephosphorylates multiple serine residues near the N terminus of NFAT proteins enabling them to translocate from cytoplasm to nucleus, where they activate a subset of hypertrophic response genes. Transgenic mice over-expressing a constitutively active form of calcineurin or NFAT3, developed obviously hypertrophy and heart failure or sudden death proving its pathogenic role. Here we used literatures on MEDLINE (2000-2011), systematically reviewed the new development of calcineurin signaling pathway in myocardial hypertrophy (J Geriatr Cardiol 2010; 7:189-192).
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1598) PDF downloads(6004) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return