Guo-Ping SHI, M.Sc., ScD, Associate Professor of Medicine, Harvard Medical School, and Biochemist, Brigham and Women’s Hospital, Boston, Massachusetts, USA. Dr.SHI received his M.Sc. degree from Beijing Agriculture University, Beijing, China, in 1987, and his ScD degree from Harvard School of Public Health, Boston, Massachusetts, USA, in 1995. Dr.SHI pioneered the fields of cysteine protease cathepsins and inflammatory mast cells in atherosclerosis, abdominal aortic aneurysms, obesity, and diabetes. He has published 14 patents, 4 book chapters, and more than 200 articles with total impact factors over 1,800 and citations over 20,000. Dr.SHI is a Consulting Editor of JCI Insight and advisory board member of Acta Pharmaceutica Sinica B among many others. He also serves as an ad hoc reviewer for over 50 journals, including Science, Nature Immunology, Cancer Cell, Journal of Clinical Investigation, Circulation, and Circulation Research. Dr.SHI is the principal investigator or co-investigator of 15 RO1 grants from the U.S. National Institutes of Health, and is the principal investigator of several past and current awards from the American Heart Association and private foundations. He is the Education Board member of American Health Council. His major honors and awards include Established Investigator Award from the American Heart Association, Award for Outstanding Research Achievement from the Nature Publishing Group, and Albrecht Fleckenstein Memorial Award for distinguished contribution in basic research from the International Academy of Cardiology. Dr.SHI’s laboratory at Brigham and Women’s Hospital and Harvard Medical School focuses mainly on the roles of cysteinyl cathepsins, mast cells, and immunoglobulin molecules in atherosclerosis, abdominal aortic aneurysms, obesity, and diabetes. Many of Dr. SHI’s discoveries have been applied to the development of small molecule compounds for the therapeutics of these common human diseases.